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Breast cancer clinical trials in Los Angeles

Clinical trials are research studies that test new ways to treat, find or manage breast cancer. Some compare a new medicine or combination with today’s standard treatment. Others study surgery, radiation, imaging or ways to ease side effects and support recovery.

Each study has its own rules about who can join. For breast cancer these often include hormone receptor (ER/PR) and HER2 status, the stage, inherited gene results such as BRCA1 or BRCA2, and past treatments.

The list below shows breast cancer studies on ClinicalTrials.gov, the public U.S. registry, that list at least one recruiting site within about 50 miles of downtown Los Angeles.

Answer 4 quick questions →No records needed. See how many recruiting studies may fit. Call Aria (855) 606-1679CureGate’s assistant, in English or Spanish.

Clinical trials are research and are not guaranteed to help. CureGate does not provide medical advice.

186 recruiting breast cancer studies near Los Angeles

Data from ClinicalTrials.gov as of November 3, 2026. Study status can change at any time. Titles are shown as registered. Confirm details with each study team.

  1. A Study Evaluating the Efficacy and Safety of Multiple Treatment Combinations in Participants With Breast Cancer

    Phase
    1/2
    Recruiting in
    Duarte, Irvine, Santa Monica
    Last updated

  2. Adding an Immunotherapy Drug, MEDI4736 (Durvalumab), to the Usual Chemotherapy Treatment (Paclitaxel, Cyclophosphamide, and Doxorubicin) for Stage II-III Breast Cancer

    Phase
    3
    Recruiting in
    Beverly Hills, Duarte, Irvine, Lancaster, Long Beach, Los Angeles, Newport Beach, Orange, Pasadena, Santa Monica, South Pasadena, Tarzana, Torrance, Upland, Yorba Linda
    Last updated

  3. Immune Response Activation for the Treatment of Unresectable Metastatic Colorectal Cancer or CEA Positive Metastatic Breast Cancer

    Phase
    1
    Recruiting in
    Duarte
    Last updated

  4. A Clinical Study of Patritumab Deruxtecan to Treat Breast Cancer (MK-1022-016)

    Phase
    3
    Recruiting in
    Los Angeles, Newport Beach
    Last updated

  5. To Study the Effect of Inavolisib in Combination With Fulvestrant in Participants With Breast Cancer

    Phase
    2
    Recruiting in
    Los Angeles
    Last updated

  6. Testing Whether Hormone Therapy With Ribociclib is as Effective as Chemotherapy Followed by Hormone Therapy With Ribociclib for the Treatment of High Anatomic Stage Breast Cancer With Low Recurrence Risk, The RxFINE-Low Trial

    Phase
    3
    Recruiting in
    Beverly Hills, Irvine, Orange, Pasadena, Tarzana, Yorba Linda
    Last updated

  7. A Phase II Study Evaluating the Efficacy and Safety of Inavolisib Plus Ribociclib Plus Fulvestrant Versus Placebo Plus Ribociclib Plus Fulvestrant in Participants With Advanced Breast Cancer

    Phase
    2
    Recruiting in
    Anaheim
    Last updated

  8. Targeted Therapy Directed by Genetic Testing in Treating Patients With Locally Advanced or Advanced Solid Tumors, The ComboMATCH Screening Trial

    Phase
    2
    Recruiting in
    Los Angeles, Orange, Santa Monica
    Last updated

  9. Study of RGT-490 in Patients With PIK3CA-Mutated Advanced Solid Tumors

    Phase
    1
    Recruiting in
    Los Angeles
    Last updated

  10. Ivermectin in Combination With Balstilimab or Pembrolizumab in Patients With Metastatic Triple Negative Breast Cancer and HR+/HER2- Metastatic Breast Cancer

    Phase
    1/2
    Recruiting in
    Los Angeles
    Last updated

  11. Saruparib (AZD5305) Plus Camizestrant or Plus Endocrine Therapy, Compared With CDK4/6 Inhibitor Plus Endocrine Therapy or Plus Camizestrant in HR-Positive, HER2-Negative (IHC 0, 1+, 2+/ ISH Non-amplified), BRCA1, BRCA2, or PALB2m Advanced Breast Cancer

    Phase
    3
    Recruiting in
    Fountain Valley, Glendale, Los Angeles, Newport Beach
    Last updated

  12. Study of XB010 in Subjects With Solid Tumors

    Phase
    1
    Recruiting in
    Irvine, Los Angeles
    Last updated

  13. A Study With NKT3964 for Adults With Advanced/Metastatic Solid Tumors

    Phase
    1
    Recruiting in
    Los Angeles
    Last updated

  14. Ultra-hypofractionated Whole Breast Irradiation With Lumpectomy Cavity Boost for the Treatment of Stage I-III Breast Cancer

    Phase
    2
    Recruiting in
    Arcadia, Duarte, Lancaster, South Pasadena, Torrance, Upland
    Last updated

  15. ROSETTA Breast-01: The Effects and Safety of Pumitamig in Patients With Triple-Negative Breast Cancer

    Phase
    3
    Recruiting in
    Los Alamitos, Los Angeles, Santa Monica
    Last updated

  16. Environmental Exposure Assessment in High-Risk and Early-Onset Breast Cancer Care

    Phase
    not listed
    Recruiting in
    Duarte
    Last updated

  17. A Phase 2 Neoadjuvant Study of Zanidatamab in Combination With Chemotherapy in Participants With HER2-positive Breast Cancer

    Phase
    2
    Recruiting in
    Long Beach, Los Alamitos, Los Angeles
    Last updated

  18. S1501 Dual Observational and Randomized Cohort Study of Patients With Metastatic HER-2+ Breast Cancer at Risk of Cardiac Toxicity

    Phase
    3
    Recruiting in
    Duarte, Los Angeles, Newport Beach, South Pasadena, Torrance, Upland
    Last updated

  19. Collecting Blood Samples From Patients With and Without Cancer to Evaluate Tests for Early Cancer Detection

    Phase
    not listed
    Recruiting in
    Burbank, Long Beach
    Last updated

  20. A Study of MGC026 in Participants With Advanced Solid Tumors

    Phase
    1
    Recruiting in
    Los Angeles
    Last updated

  21. Beamion BCGC-1: A Study to Find a Suitable Dose of Zongertinib Used Alone and in Combination With Other Treatments to Test Whether it Helps People With Different Types of HER2+ Cancer That Has Spread

    Phase
    1/2
    Recruiting in
    Cerritos, Los Angeles, Orange
    Last updated

  22. A Dose Randomization Study of Bulumtatug Fuvedotin in TNBC Patients Previously Treated With ADCs

    Phase
    1
    Recruiting in
    Duarte
    Last updated

  23. A Phase 1/2 Trial of TER-2013 in Patients With Solid Tumors Harboring AKT/PI3K/PTEN Pathway Alterations

    Phase
    1/2
    Recruiting in
    Duarte, Irvine
    Last updated

  24. An Open-label, Single-arm Study of Prophylaxis for Datopotamab Deruxtecan (Dato-DXd) -Related Stomatitis in Eligible Patients With Metastatic or Inoperable Locally Recurrent Breast Cancer or Locally Advanced or Metastatic Epidermal Growth Factor Receptor-Mutated Non-small Cell Lung Cancer.

    Phase
    4
    Recruiting in
    Glendale, Lakewood, Long Beach
    Last updated

  25. EXActDNA-003 / NSABP B-64: Study of Molecular Residual Disease Detection in Breast Cancer (MRD)

    Phase
    not listed
    Recruiting in
    Torrance
    Last updated

  26. A Study of LY4337713 in Participants With FAP-Positive Solid Tumors

    Phase
    1
    Recruiting in
    Newport Beach
    Last updated

  27. Solid Tumor Analysis for HLA Loss of Heterozygosity (LOH) and Apheresis for CAR T- Cell Manufacturing

    Phase
    not listed
    Recruiting in
    Santa Monica
    Last updated

  28. DCIS: RECAST Trial Ductal Carcinoma In Situ: Re-Evaluating Conditions for Active Surveillance Suitability as Treatment

    Phase
    2
    Recruiting in
    Duarte, Irvine, Los Angeles, South Pasadena
    Last updated

  29. A Study of HER3-DXd in Subjects With Locally Advanced or Metastatic Solid Tumors

    Phase
    2
    Recruiting in
    Duarte
    Last updated

  30. A Study to Evaluate the Efficacy and Safety of Ifinatamab Deruxtecan (I-DXd) in Subjects With Recurrent or Metastatic Solid Tumors (IDeate-PanTumor02)

    Phase
    1/2
    Recruiting in
    Los Angeles, Whittier
    Last updated

  31. A Study to Test Inavolisib Treatments in Participants With Early-Stage, PIK3CA-Mutated Breast Cancer

    Phase
    2
    Recruiting in
    Los Angeles, Orange
    Last updated

  32. A Study to Evaluate the Effect of GDC-4198 Alone and in Combination With Giredestrant Versus Abemaciclib and Giredestrant in Participants With Locally Advanced or Metastatic Estrogen Receptor-Positive (ER+), Human Epidermal Growth Factor Receptor-Negative (HER2-) Breast Cancer

    Phase
    1/2
    Recruiting in
    Duarte, Irvine
    Last updated

  33. A Study of LY4257496 in Participants With Cancer (OMNIRAY)

    Phase
    1
    Recruiting in
    Duarte, Santa Monica
    Last updated

  34. BGB-43395 Plus Letrozole Versus CDK4/6i Plus Letrozole for Patients With Advanced or Metastatic HR+/HER2- Breast Cancer Who Have Not Received Prior Treatment for Advanced or Metastatic Disease

    Phase
    3
    Recruiting in
    Duarte, Fountain Valley, Los Angeles, Santa Monica, West Hills
    Last updated

  35. S1703 Serum Tumor Marker Directed Disease Monitoring in Patients With Hormone Receptor Positive Her2 Negative Metastatic Breast Cancer

    Phase
    Not applicable
    Recruiting in
    Anaheim, Baldwin Park, Bellflower, Burbank, Fontana, Irvine, Los Angeles, Ontario, Panorama City, Riverside, Woodland Hills
    Last updated

  36. A Study of LY4052031 in Participants With Advanced or Metastatic Urothelial Cancer or Other Solid Tumors

    Phase
    1
    Recruiting in
    Duarte, Los Angeles
    Last updated

  37. Study of AMXT 1501 and DFMO in Combination With Standard Therapies in Advanced Solid Tumors

    Phase
    1/2
    Recruiting in
    Los Angeles
    Last updated

  38. A Study of Mutant Selective-Inhibitor (CGT6297), in Patients With Advanced Solid Tumors

    Phase
    1
    Recruiting in
    Los Angeles
    Last updated

  39. Study of PF-07248144 in Advanced or Metastatic Solid Tumors

    Phase
    2
    Recruiting in
    Los Angeles
    Last updated

  40. Intratumoral N17350 in Advanced Solid Tumors

    Phase
    1/2
    Recruiting in
    Los Angeles
    Last updated

  41. Safety, PK and Efficacy of QXL138AM in Patients With Solid Tumors and Multiple Myeloma

    Phase
    1
    Recruiting in
    Los Angeles
    Last updated

  42. A Study Evaluating Adherence, Tolerability, and Patient Reported Outcomes of Giredestrant in Participants With ER+/HER2- Early Breast Cancer Who Are Intolerant to Adjuvant Aromatase Inhibitor Therapy (novERA Breast Cancer)

    Phase
    3
    Recruiting in
    Fountain Valley
    Last updated

  43. Post-Marketing Study for Early-Stage Low-Risk Breast Cancer Treatment Using ProSense® Cryoablation (ChoICE Trial)

    Phase
    Not applicable
    Recruiting in
    Glendale
    Last updated

  44. Metformin for the Treatment of Insulin Resistance in Women With Stage I-III Breast Cancer Completing Chemotherapy

    Phase
    3
    Recruiting in
    Duarte
    Last updated

  45. Evaluation of the Safety and Efficacy of Treatment w/High Dose Melphalan Given Directly Into the Liver Followed by Treatment w/Approved Cancer Treatment or Approved Cancer Treatment Alone in Patients w/ Metastatic Breast Cancer w/Liver Dominant Disease

    Phase
    2
    Recruiting in
    Santa Monica
    Last updated

  46. A Study to Learn About the Study Medicine Called PF-07248144 in Combination With Fulvestrant in People With HR-positive, HER2-negative Advanced or Metastatic Breast Cancer Who Progressed After a Prior Line of Treatment.

    Phase
    3
    Recruiting in
    Anaheim, Camarillo, Fountain Valley, Glendale, Los Angeles, Torrance, Van Nuys
    Last updated

  47. Abemaciclib and Endocrine Therapy in Older Patients With Breast Cancer.

    Phase
    2
    Recruiting in
    Duarte, Irvine, Long Beach, South Pasadena
    Last updated

  48. A Study to Evaluate the Efficacy and Safety of Inavolisib in Combination With Phesgo Versus Placebo in Combination With Phesgo in Participants With PIK3CA-Mutated HER2-Positive Locally Advanced or Metastatic Breast Cancer

    Phase
    3
    Recruiting in
    Burbank, Corona, Duarte, Irvine, Los Angeles
    Last updated

  49. A Blended e-Health Intervention to Improve Fear of Progression in Women With Gynecologic or Breast Cancer

    Phase
    Not applicable
    Recruiting in
    Arcadia, Duarte, Huntington Beach, Irvine, Lancaster, Long Beach, Santa Clarita, Simi Valley, South Pasadena, Upland, West Covina
    Last updated

  50. Anastrazole, Fulvestrant & Abemaciclib for HR+HER2- Metastatic Breast Cancer

    Phase
    2
    Recruiting in
    Orange
    Last updated

  51. SMP-3124LP in Adults With Advanced Solid Tumors

    Phase
    1/2
    Recruiting in
    Los Angeles
    Last updated

  52. A Clinical Study to Find the Optimal Dose of an Investigational Treatment Called BNT323 When Used in Combination With Another Investigational Treatment, BNT327, and to Test if That Combination Treatment is Safe and Beneficial for Patients With Advanced Breast Cancer

    Phase
    1/2
    Recruiting in
    Beverly Hills, Newport Beach
    Last updated

  53. Study to Assess Adverse Events and Change in Disease Activity in Adult Participants With Select Advanced Solid Tumor Indications Receiving Intravenous (IV) ABBV-400

    Phase
    1
    Recruiting in
    Duarte
    Last updated

  54. A Study of Metastases Free Survival With Saruparib vs Placebo Added to a Standard RT/ADT in Men With High-risk Prostate Cancer With a BRCA Mutation

    Phase
    3
    Recruiting in
    Los Angeles
    Last updated

  55. A Phase I/IIa Study of AZD8205 Given Alone or Combined, in Participants With Advanced/Metastatic Solid Malignancies

    Phase
    1/2
    Recruiting in
    Santa Monica
    Last updated

  56. Study of Sacituzumab Govitecan-hziy and Pembrolizumab Versus Treatment of Physician's Choice in Patients With Triple Negative Breast Cancer Who Have Residual Invasive Disease After Surgery and Neoadjuvant Therapy (ASCENT-05/AFT-65 OptimICE-RD/GBG 119/NSABP B-63)

    Phase
    3
    Recruiting in
    Downey, Los Angeles, Newport Beach
    Last updated

  57. Open Label Study to Evaluate BL-M07D1 in HER2 Expressing Malignant Solid Tumors

    Phase
    1
    Recruiting in
    Duarte, Los Angeles
    Last updated

  58. A Study of Sacituzumab Tirumotecan (MK-2870) as a Single Agent and in Combination With Pembrolizumab (MK-3475) Versus Treatment of Physician's Choice in Participants With HR+/HER2- Unresectable Locally Advanced or Metastatic Breast Cancer (MK-2870-010)

    Phase
    3
    Recruiting in
    Fullerton
    Last updated

  59. Sacituzumab Tirumotecan (MK-2870) Plus Pembrolizumab Versus TPC in TNBC Who Did Not Achieve pCR (MK-2870-012)

    Phase
    3
    Recruiting in
    Fountain Valley
    Last updated

  60. A Study of Sacituzumab Tirumotecan (Sac-TMT, MK-2870) as Monotherapy and in Combination With Pembrolizumab (MK-3475) in Participants With Triple-Negative Breast Cancer (MK-2870-011/TroFuse-011)

    Phase
    3
    Recruiting in
    Duarte, Irvine, Los Angeles
    Last updated

  61. A Clinical Study of Sacituzumab Tirumotecan (Sac-TMT, MK-2870) in People With Breast Cancer (MK-2870-032)

    Phase
    3
    Recruiting in
    Burbank, Fullerton, Long Beach, Newport Beach, Whittier
    Last updated

  62. Phase 1/2 Study of ETX-636 in Participants With Advanced Solid Tumors

    Phase
    1/2
    Recruiting in
    Newport Beach
    Last updated

  63. A Study Evaluating the Efficacy and Safety of Multiple Treatment Combinations in Patients With Metastatic or Locally Advanced Breast Cancer

    Phase
    1/2
    Recruiting in
    Duarte, Irvine, Los Angeles
    Last updated

  64. Study of Abemaciclib and Elacestrant in Participants With Brain Metastasis Due to ER+/HER-2- Breast Cancer

    Phase
    1/2
    Recruiting in
    Fullerton, Los Angeles
    Last updated

  65. Phase 3 Study of Gedatolisib as First-Line Treatment for Patients With HR-Positive, HER2-Negative Advanced Breast Cancer (VIKTORIA-2)

    Phase
    3
    Recruiting in
    Fullerton, Los Angeles
    Last updated

  66. A Study to Compare the Steady-State Bioavailability of Injectable Letrozole SIE and Oral Letrozole in Post-Menopausal Women With Hormone Receptor Positive Early Breast Cancer

    Phase
    1
    Recruiting in
    Beverly Hills
    Last updated

  67. A Study of Tersolisib (LY4064809/STX-478) With Other Anti-Cancer Treatments in Participants With Advanced Breast Cancer With a Genetic Change (PIK3CA)

    Phase
    3
    Recruiting in
    Duarte, Irvine
    Last updated

  68. Rinatabart Sesutecan (Rina-S, PRO1184, GEN1184) for Advanced Solid Tumors (GCT1184-01/ PRO1184-001)

    Phase
    1/2
    Recruiting in
    Los Angeles
    Last updated

  69. Stereotactic Body Radiation Therapy and FES PET/CT Imaging for the Treatment of Oligoprogressive Estrogen Receptor Positive Metastatic Breast Cancer

    Phase
    2
    Recruiting in
    Duarte, Irvine
    Last updated

  70. A Study Evaluating the Efficacy and Safety of Inavolisib Plus CDK4/6 Inhibitor and Letrozole vs Placebo + CDK4/6i and Letrozole in Participants With Endocrine-Sensitive PIK3CA-Mutated, Hormone Receptor-Positive, HER2-Negative Advanced Breast Cancer

    Phase
    3
    Recruiting in
    Burbank, Irvine, Long Beach, Los Alamitos, Los Angeles
    Last updated

  71. A Phase 1 Study of BMS-986500 as Monotherapy or Combination Therapy in Advanced Solid Tumors

    Phase
    1
    Recruiting in
    Fullerton, Newport Beach
    Last updated

  72. Study of AZD9574 as Monotherapy and in Combination With Anti-cancer Agents in Participants With Advanced Solid Malignancies

    Phase
    1/2
    Recruiting in
    Los Angeles
    Last updated

  73. A Study of PHST001 in Advanced Solid Tumors

    Phase
    1
    Recruiting in
    Beverly Hills, Los Angeles
    Last updated

  74. Phase 3 Study of RLY-2608 + Fulvestrant vs Capivasertib + Fulvestrant as Treatment for Locally Advanced or Metastatic PIK3CA-mutant HR+/HER2- Breast Cancer

    Phase
    3
    Recruiting in
    Beverly Hills, Duarte, Los Angeles
    Last updated

  75. The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)

    Phase
    1/2
    Recruiting in
    Los Angeles
    Last updated

  76. A Study to Learn More About How Well Treatment With Sevabertinib (BAY 2927088) Tablets Works and How Safe it is in Participants Who Have a Solid Tumor With Mutations of the Human Epidermal Growth Factor Receptor 2 (HER2)

    Phase
    2
    Recruiting in
    Duarte
    Last updated

  77. ShortStop-HER2: 12 Months vs. 6 Months of HER2-targeted Medications for People With HER2+ Breast Cancer Who Had a Pathologic Complete Response After Chemotherapy Plus Trastuzumab

    Phase
    3
    Recruiting in
    Beverly Hills, Irvine, Orange, Pasadena, Santa Monica, Tarzana, Torrance, Yorba Linda
    Last updated

  78. A Study of Alisertib in Combination With Endocrine Therapy in Patients With HR-positive, HER2-negative Recurrent or Metastatic Breast Cancer

    Phase
    2
    Recruiting in
    Beverly Hills, Fountain Valley, Irvine, Los Angeles
    Last updated

  79. Open-Label Study of BBO-10203 in Subjects With Advanced Solid Tumors

    Phase
    1
    Recruiting in
    Duarte, Los Angeles
    Last updated

  80. A Study of NT-175 in Adult Participants With Advanced Malignancies That Are Positive for HLA-A*02:01 and the TP53 R175H Mutation

    Phase
    1
    Recruiting in
    Duarte, Los Angeles, Newport Beach, Santa Monica
    Last updated

  81. IKS014 in Advanced Solid Tumors That Express HER2

    Phase
    1
    Recruiting in
    Newport Beach
    Last updated

  82. A Phase III Study of Dato-DXd With or Without Durvalumab Compared With Investigator's Choice of Chemotherapy in Combination With Pembrolizumab in Patients With PD-L1 Positive Locally Recurrent Inoperable or Metastatic Triple-negative Breast Cancer (TROPION-Breast05)

    Phase
    3
    Recruiting in
    Glendale
    Last updated

  83. ASPEN-09-03: A Study of Evorpacept in Combination With Trastuzumab and Chemotherapy in Metastatic HER2-Positive Breast Cancer

    Phase
    2
    Recruiting in
    Duarte, Orange
    Last updated

  84. A Study of KIVU-107 in Participants With Locally Advanced or Metastatic Solid Tumors

    Phase
    1
    Recruiting in
    Santa Monica
    Last updated

  85. Palazestrant in Combination With Ribociclib for the First-line Treatment of ER+/HER2- Advanced Breast Cancer

    Phase
    3
    Recruiting in
    Beverly Hills, Los Alamitos
    Last updated

  86. A Study of ASP546C in Adults With Gastroesophageal Cancer, Pancreatic Cancer or Other Solid Tumors

    Phase
    1/2
    Recruiting in
    Los Angeles
    Last updated

  87. Women Informed to Screen Depending on Measures of Risk (Wisdom Study)

    Phase
    Not applicable
    Recruiting in
    Irvine, Los Angeles
    Last updated

  88. Evaluate BL-B01D1 in Patients With Metastatic or Unresectable Non-Small Cell Lung Cancer (NSCLC) and Other Solid Tumors

    Phase
    1
    Recruiting in
    Beverly Hills, Duarte, Orange, Santa Monica
    Last updated

  89. A Study of [225Ac]Ac-AKY-1189 in Patients With Solid Tumors

    Phase
    1
    Recruiting in
    Duarte, Irvine
    Last updated

  90. Neoadjuvant INBRX-106 in Combination With Pembrolizumab for Stage II/III TNBC Patients

    Phase
    2
    Recruiting in
    Los Angeles
    Last updated

  91. A Study of Elacestrant Versus Standard Endocrine Therapy in Women and Men With ER+,HER2-, Early Breast Cancer With High Risk of Recurrence

    Phase
    3
    Recruiting in
    Beverly Hills, Duarte, Irvine, Long Beach, Los Alamitos, Los Angeles, Newport Beach, Orange, Torrance
    Last updated

  92. ORACLE: Observation of ResiduAl Cancer With Liquid Biopsy Evaluation

    Phase
    not listed
    Recruiting in
    Newport Beach
    Last updated

  93. Study of Patritumab Deruxtecan Plus Pembrolizumab With Other Anticancer Agents in Participants With High-Risk Early-Stage Triple-Negative or Hormone Receptor-Low Positive/HER-2 Negative Breast Cancer (MK-1022-010, HERTHENA-Breast-03)

    Phase
    2
    Recruiting in
    Santa Monica
    Last updated

  94. A Phase 1/1b Study of IAM1363 in HER2 Cancers

    Phase
    1
    Recruiting in
    Los Angeles
    Last updated

  95. A Study to Evaluate Safety, Tolerability and Preliminary Activity of AGX101 in Participants With Advanced Solid Tumors

    Phase
    1
    Recruiting in
    Los Angeles
    Last updated

  96. Study of ORIC-114 in Patients With Advanced Solid Tumors Harboring an EGFR or HER2 Alteration

    Phase
    1/2
    Recruiting in
    Duarte, Huntington Beach, Irvine, Long Beach
    Last updated

  97. Evaluating Minimal Residual Disease (MRD) Through Longitudinal Circulating Tumor DNA (ctDNA) Profiling in Breast Malignancies

    Phase
    not listed
    Recruiting in
    Whittier
    Last updated

  98. Evaluating the Addition of Adjuvant Chemotherapy to Ovarian Function Suppression Plus Endocrine Therapy in Premenopausal Patients With pN0-1, ER-Positive/HER2-Negative Breast Cancer and an Oncotype Recurrence Score Less Than or Equal to 25

    Phase
    3
    Recruiting in
    Anaheim, Baldwin Park, Bellflower, Beverly Hills, Buena Park, Burbank, Fontana, Harbor City, Irvine, Los Angeles, Ontario, Orange, Panorama City, Pasadena, Pomona, Riverside, Tarzana, Torrance, Woodland Hills
    Last updated

  99. Study of the Bria-IMT Regimen and CPI vs Physicians' Choice in Advanced Metastatic Breast Cancer.

    Phase
    3
    Recruiting in
    Anaheim, Beverly Hills, Corona, Fountain Valley, Glendale, Irvine, Los Angeles, Pasadena, Riverside, Santa Monica, Torrance, Van Nuys, West Hollywood
    Last updated

  100. FT836 With or Without Chemotherapy and/or Monoclonal Antibodies, in Participants With Advanced Solid Tumors

    Phase
    1
    Recruiting in
    Los Angeles
    Last updated

  101. A Study of Oral MBQ-167 in Participants With Advanced Breast Cancer

    Phase
    1
    Recruiting in
    Beverly Hills
    Last updated

  102. A Study With NKT5097 for Adults With Advanced/Metastatic Solid Tumors

    Phase
    1
    Recruiting in
    Duarte
    Last updated

  103. Study of ECI830 Single Agent or in Combination in Patients With Advanced HR+/HER2- Breast Cancer and in Patients With Other Advanced Solid Tumors

    Phase
    1/2
    Recruiting in
    Los Angeles
    Last updated

  104. A Pivotal Phase II Clinical Trial of Utidelone Injection Plus Capecitabine in HER2-negative Breast Cancer Patients With Brain Metastases

    Phase
    2
    Recruiting in
    Duarte, Los Angeles
    Last updated

  105. Imlunestrant and Abemaciclib for the Treatment of Estrogen Receptor Positive Breast Cancer in Patients With Minimal Residual Disease, MIRI Trial

    Phase
    2
    Recruiting in
    Los Angeles
    Last updated

  106. A Study of BMS-986340 as Monotherapy and as Combination Therapy in Participants With Advanced Solid Tumors

    Phase
    1/2
    Recruiting in
    Los Angeles, Newport Beach
    Last updated

  107. Study to Assess GTAEXS617 in Participants With Advanced Solid Tumors

    Phase
    1/2
    Recruiting in
    Los Angeles
    Last updated

  108. FIH Study of RGT-419B Alone and With Endocrine Therapy in HR-Positive, HER2-Negative Advanced/Metastatic Breast Cancer

    Phase
    1
    Recruiting in
    Los Angeles
    Last updated

  109. IIT2023-09-Chung-UpfrontTAD: Upfront TAD/SNB in Patients With Breast Cancer With Nodal Metastases

    Phase
    2
    Recruiting in
    Los Angeles, Pasadena, Tarzana
    Last updated

  110. A Study of Izalontamab Brengitecan Versus Chemotherapy in Participants With Previously Untreated, Locally Advanced, Recurrent Inoperable, or Metastatic Triple-negative Breast Cancer Ineligible for Anti-PD(L)1 Drugs (IZABRIGHT-Breast01)

    Phase
    2/3
    Recruiting in
    Cerritos, Los Angeles, Newport Beach
    Last updated

  111. ORION-1: Study of AVZO-023 as a Single Agent and in Combination With AVZO-021, and/or Endocrine Therapy in Advanced Solid Tumors

    Phase
    1/2
    Recruiting in
    Los Angeles
    Last updated

  112. A First-in-Human Study of MEN2312 in Adults With Advanced Breast Cancer

    Phase
    1
    Recruiting in
    Duarte, Santa Monica
    Last updated

  113. Phase 3 Study to Evaluate the Efficacy and Safety of HER2/Neu Peptide GLSI-100 (GP2 + GM-CSF) in HER2/Neu Positive Subjects

    Phase
    3
    Recruiting in
    Duarte, Fullerton, Irvine, Santa Monica, Whittier
    Last updated

  114. Pembrolizumab vs. Observation in People With Triple-negative Breast Cancer Who Had a Pathologic Complete Response After Chemotherapy Plus Pembrolizumab

    Phase
    3
    Recruiting in
    Beverly Hills, Los Angeles, Orange, Pasadena, Santa Monica, Tarzana, Torrance
    Last updated

  115. Tart Cherry and Omega-3's for Aromatase Inhibitor Musculoskeletal Symptoms

    Phase
    Early Phase 1
    Recruiting in
    Los Angeles
    Last updated

  116. E-Mindfulness Approaches for Living After Breast Cancer

    Phase
    3
    Recruiting in
    Anaheim, Baldwin Park, Bellflower, Costa Mesa, Fontana, Harbor City, Irvine, Los Angeles, Ontario, Orange, Panorama City, Riverside, Santa Clarita, Woodland Hills, Yorba Linda
    Last updated

  117. Phase II Trial of Ivonescimab in Combination With Carboplatin + Docetaxel in Patients With Early-Stage Triple Negative Breast Cancer

    Phase
    2
    Recruiting in
    Los Angeles, Torrance
    Last updated

  118. Testing the Safety and Efficacy of the Combination of Two Anti-cancer Drugs, ZEN003694 and Abemaciclib, for Adult and Pediatric Patients (12-17 Years) With Metastatic or Unresectable NUT Carcinoma, Breast Cancer and Other Solid Tumors

    Phase
    1
    Recruiting in
    Los Angeles, Newport Beach
    Last updated

  119. Prevention of Frailty With Fisetin and Exercise in Breast Cancer Survivors

    Phase
    2
    Recruiting in
    Alhambra, Beverly Hills, Burbank, Los Angeles, Marina del Rey, Pasadena
    Last updated

  120. Phase I Study of [177Lu]Lu-NNS309 in Patients With Pancreatic, Lung, Breast and Colorectal Cancers

    Phase
    1
    Recruiting in
    Los Angeles
    Last updated

  121. Gene Therapy for HER-Positive Cancer (SENTRY-HER2)

    Phase
    1/2
    Recruiting in
    Los Angeles
    Last updated

  122. A Study to Assess the Efficacy and Safety of FORE8394 in Participants With Cancer Harboring BRAF Alterations

    Phase
    2
    Recruiting in
    Beverly Hills, Westwood, Los Angeles
    Last updated

  123. A Study of PF-08046054/SGN-PDL1V in Advanced Solid Tumors

    Phase
    1
    Recruiting in
    Irvine, Orange
    Last updated

  124. A Study to Learn About the Study Medicine Called PF-08032562 in People With Advanced or Metastatic Solid Tumors

    Phase
    1
    Recruiting in
    Duarte
    Last updated

  125. Fisetin to Improve Physical Function in Stage I-III Breast Cancer Survivors

    Phase
    2
    Recruiting in
    Alhambra, Beverly Hills, Burbank, Duarte, Los Angeles, Marina del Rey, Pasadena
    Last updated

  126. Trial of Single Protein Encapsulated Doxorubicin, SPEDOX-6 in Advanced Malignancies

    Phase
    1/2
    Recruiting in
    Orange
    Last updated

  127. Repurposing Riluzole for Cancer-Related Cognitive Impairment: A Pilot Trial

    Phase
    2
    Recruiting in
    Orange
    Last updated

  128. Brain Health in Breast Cancer Survivors

    Phase
    not listed
    Recruiting in
    Los Angeles
    Last updated

  129. First-in-Human Study of Tersolisib (STX-478) as Monotherapy and in Combination With Other Antineoplastic Agents in Participants With Advanced Solid Tumors

    Phase
    1/2
    Recruiting in
    Los Angeles
    Last updated

  130. Acolbifene Versus Low Dose Tamoxifen for the Prevention of Breast Cancer in Premenopausal Women at High Risk for Development of Breast Cancer

    Phase
    2
    Recruiting in
    Duarte
    Last updated

  131. A Study of Sigvotatug Vedotin in Advanced Solid Tumors

    Phase
    1
    Recruiting in
    Anaheim, Fullerton, Los Angeles, Santa Monica
    Last updated

  132. Navigation Intervention for Adolescent and Young Adult Cancer Survivors

    Phase
    Not applicable
    Recruiting in
    Pasadena
    Last updated

  133. Sapanisertib and Serabelisib (PIKTOR) in Various Combinations in Patients With HR+/HER2- Advanced/Metastatic Breast Cancer

    Phase
    1/2
    Recruiting in
    Los Angeles
    Last updated

  134. An Investigational Scan (64Cu-DOTA-Trastuzumab PET/MRI) in Imaging Patients With HER2+ Breast Cancer With Brain Metastasis

    Phase
    4
    Recruiting in
    Duarte
    Last updated

  135. EXoPERT EMERALD Clinical Study

    Phase
    not listed
    Recruiting in
    Long Beach, Los Angeles
    Last updated

  136. A Study of Emiltatug Ledadotin (Emi-Le) in Participants With Solid Tumors

    Phase
    1/2
    Recruiting in
    Orange, Santa Monica
    Last updated

  137. A Long-term Treatment Extension Study of Niraparib in Participants Who Completed a Prior GlaxoSmithKline/TESARO-sponsored Niraparib Study

    Phase
    2
    Recruiting in
    Los Angeles
    Last updated

  138. Investigating the Feasibility and Acceptability of an Innovative Interdisciplinary Supportive Care Program: Couples Coping Together Against Cancer

    Phase
    not listed
    Recruiting in
    Duarte
    Last updated

  139. Study to Assess Adverse Events and Pharmacokinetics in Adult Participants With Non-Small Cell Lung Cancer, Head and Neck Squamous Cell Carcinoma and Other Solid Tumors, Receiving Intravenous Infusion of Azirkitug Alone or in Combination(s) With Budigalimab, Bevacizumab, or Telisotuzumab Adizutecan

    Phase
    1
    Recruiting in
    Duarte, Irvine, Los Angeles
    Last updated

  140. Dose Determining Study of EXS74539 (REC-4539) in Participants With Select Solid Tumors

    Phase
    1
    Recruiting in
    Los Angeles
    Last updated

  141. Increasing Germline Genetic Testing for Patients With Cancer

    Phase
    Not applicable
    Recruiting in
    Los Angeles
    Last updated

  142. Study of CX-5461 in Patients With Solid Tumours and BRCA1/2, PALB2 or Homologous Recombination Deficiency (HRD) Mutation

    Phase
    1
    Recruiting in
    Santa Monica
    Last updated

  143. Manual Lymphatic Drainage Breast Massage in Breast Cancer Patients After Breast Conserving Surgery

    Phase
    Not applicable
    Recruiting in
    Los Angeles
    Last updated

  144. Breast Cancer Screening Adherence for Women at Moderate Risk for Breast Cancer

    Phase
    not listed
    Recruiting in
    Los Angeles
    Last updated

  145. Breast Cancer Survivorship Biorepository

    Phase
    not listed
    Recruiting in
    Los Angeles
    Last updated

  146. Cemiplimab and Transarterial Radioembolization With Y-90 SIR-S Spheres for the Treatment of Liver Directed Metastatic Breast Cancer

    Phase
    2
    Recruiting in
    Duarte
    Last updated

  147. A2-ESO-1 TCR-Engineered T Cells for Relapsed/Refractory Advanced or Metastatic NY-ESO-1 Overexpression Positive Triple Negative Breast Cancer

    Phase
    1
    Recruiting in
    Los Angeles
    Last updated

  148. Core Biopsies for Establishing a Breast Tumor Tissue Repository

    Phase
    not listed
    Recruiting in
    Los Angeles
    Last updated

  149. I-SPY TRIAL: Neoadjuvant and Personalized Adaptive Novel Agents to Treat Breast Cancer

    Phase
    2
    Recruiting in
    Duarte, Los Angeles, Newport Beach
    Last updated

  150. Randomized Feasibility Trial for Mesh in Pre-Pectoral Reconstruction

    Phase
    Not applicable
    Recruiting in
    Los Angeles
    Last updated

  151. Comparative Effectiveness Trial of Two Supportive Cancer Care Delivery Models for Adults With Cancer

    Phase
    Not applicable
    Recruiting in
    Duarte, Fullerton, Los Angeles
    Last updated

  152. De-Escalation of Breast Radiation Trial for Hormone Sensitive, HER-2 Negative, Oncotype Recurrence Score Less Than or Equal to 18 Breast Cancer (DEBRA)

    Phase
    3
    Recruiting in
    Anaheim, Bellflower, Irvine, Los Angeles, Ontario, Orange, Riverside, Santa Clarita, Tarzana, Torrance
    Last updated

  153. Reinvigorating TNBC Response to Immunotherapy With Combination Myeloid Inhibition and Radiation

    Phase
    2
    Recruiting in
    Los Angeles
    Last updated

  154. Dose-Reduced Docetaxel With Cyclophosphamide for the Treatment of Vulnerable Older Women With Stage I-III HER2 Negative Breast Cancer, the DOROTHY Trial

    Phase
    2
    Recruiting in
    Duarte
    Last updated

  155. A Study of DB-1310 in Advanced/Metastatic Solid Tumors

    Phase
    1/2
    Recruiting in
    Santa Monica
    Last updated

  156. Access to Genetic Testing in Underserved Patients With Cancer

    Phase
    Not applicable
    Recruiting in
    Los Angeles
    Last updated

  157. Gene Modified Immune Cells After Conditioning Regimen for the Treatment of Stage IIIC or IV Melanoma or Metastatic Solid Tumors

    Phase
    1
    Recruiting in
    Duarte, Los Angeles
    Last updated

  158. A Validation Study to Determine Concordance of Liquid Biopsy and Breast Cancer Diagnosis

    Phase
    not listed
    Recruiting in
    Los Angeles, Newport Beach
    Last updated

  159. A Dose Finding Phase 1 of Sarilumab Plus Capecitabine in HER2/Neu-Negative Metastatic Breast Cancer and a Single-arm, Historically-controlled Phase 2 Study of Sarilumab Plus Capecitabine in Stage I-III Triple Negative Breast Cancer With High-Risk Residual Disease (EMPOWER)

    Phase
    1/2
    Recruiting in
    Los Angeles
    Last updated

  160. Riluzole For Preventing Cognitive Dysfunction in Ca Pts Receiving Chemo (REFOCUS): Pilot Trial

    Phase
    2
    Recruiting in
    Orange
    Last updated

  161. A Study of CLSP-1025 in Adult Patients With Solid Tumors That Harbor the p53 R175H Mutation

    Phase
    1
    Recruiting in
    Los Angeles
    Last updated

  162. A Study Comparing the Efficacy and Safety of Zanidatamab to Trastuzumab, Each in Combination With Physician's Choice Chemotherapy, for the Treatment of Participants With Metastatic HER2-positive Breast Cancer

    Phase
    3
    Recruiting in
    Cerritos, Glendale, Los Angeles
    Last updated

  163. Contrast Enhanced Ultrasound Medical Imaging for Identifying Breast Masses

    Phase
    1
    Recruiting in
    Los Angeles
    Last updated

  164. A Study of Sacituzumab Govitecan Given at an Alternative Dose and Schedule in Participants With Advanced Triple-Negative Breast Cancer

    Phase
    1/2
    Recruiting in
    Los Angeles
    Last updated

  165. Project SOAR (Speaking Our African American Realities) Awakenings for Black American Women Diagnosed With Breast Cancer

    Phase
    Not applicable
    Recruiting in
    Los Angeles
    Last updated

  166. cfDNA Assay Prospective Observational Validation for Early Cancer Detection and Minimal Residual Disease

    Phase
    not listed
    Recruiting in
    Duarte
    Last updated

  167. Effects of White Button Mushroom on Inflammation in Obese Postmenopausal Women at High Risk of Breast Cancer

    Phase
    Not applicable
    Recruiting in
    Duarte
    Last updated

  168. A Study of MT-4561 in Patients With Various Advanced Solid Tumors

    Phase
    1/2
    Recruiting in
    Los Angeles
    Last updated

  169. Photon Craniospinal Irradiation for the Treatment of Leptomeningeal Disease Secondary to Breast Cancer or Non-small Cell Lung Cancer

    Phase
    2
    Recruiting in
    Duarte, Irvine
    Last updated

  170. Phytocannabinoids for Reducing Chronic Chemotherapy-Induced Peripheral Neuropathy in Breast and Colon Cancer Survivors

    Phase
    2
    Recruiting in
    Duarte, Irvine
    Last updated

  171. A Trial Comparing Screening Mammography With and Without Assistance From Artificial Intelligence for Breast Cancer Detection and Recall Rates in Adult Patients

    Phase
    4
    Recruiting in
    Los Angeles
    Last updated

  172. Trastuzumab Deruxtecan Alone or in Combination With Anastrozole for the Treatment of Early Stage HER2 Low, Hormone Receptor Positive Breast Cancer

    Phase
    2
    Recruiting in
    Fullerton, Los Alamitos, Los Angeles, Torrance, Whittier
    Last updated

  173. Utilizing Advocates and Supporters to Increase Lung Cancer Screening Rates in Eligible Participants

    Phase
    Not applicable
    Recruiting in
    Los Angeles
    Last updated

  174. Shorter Chemo-Immunotherapy Without Anthracycline Drugs for Early-Stage Triple Negative Breast Cancer

    Phase
    3
    Recruiting in
    Anaheim, Baldwin Park, Bellflower, Beverly Hills, Burbank, Duarte, Fontana, Harbor City, Irvine, Lancaster, Los Angeles, Newport Beach, Ontario, Panorama City, Pasadena, Riverside, Santa Monica, South Pasadena, Tarzana, Torrance, Upland, Woodland Hills
    Last updated

  175. A Phase I/II Study of VLS-1488 in Subjects With Advanced Cancer

    Phase
    1/2
    Recruiting in
    Los Angeles, Newport Beach
    Last updated

  176. Phase 1/2 Study of Intratumoral Injection of STX-001 in Advanced Solid Tumors as Monotherapy or in Combination With Pembrolizumab

    Phase
    1/2
    Recruiting in
    Beverly Hills
    Last updated

  177. SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry

    Phase
    not listed
    Recruiting in
    Duarte, Irvine, Orange
    Last updated

  178. A Study to Evaluate TROP2 ADC LCB84 Single Agent and in Combination With an Anti-PD-1 Ab in Advanced Solid Tumors

    Phase
    1/2
    Recruiting in
    Los Angeles
    Last updated

  179. A Study of Invikafusp Alfa (STAR0602), a Selective T Cell Receptor (TCR)-Targeting, Bifunctional Antibody-fusion Molecule, in Combination With Sacituzumab Govitecan in Participants With Advanced Solid Tumors

    Phase
    1/2
    Recruiting in
    Los Angeles
    Last updated

  180. A Study of NX-1607 in Adults With Advanced Malignancies

    Phase
    1
    Recruiting in
    Los Angeles
    Last updated

  181. A Study to Evaluate the Safety and Efficacy of A2B395, an Allogeneic Logic-gated CAR T, in Participants With Solid Tumors That Express EGFR and Have Lost HLA-A*02 Expression

    Phase
    1/2
    Recruiting in
    Los Angeles
    Last updated

  182. MammaPrint, BluePrint, and Full-genome Data Linked With Clinical Data to Evaluate New Gene EXpression Profiles

    Phase
    not listed
    Recruiting in
    Van Nuys
    Last updated

  183. A Trial of AMXI-5001 for Treatment in Patients With Advanced Malignancies

    Phase
    1/2
    Recruiting in
    Los Angeles
    Last updated

  184. Clinical Validation of the Role of microRNA Binding Site Mutations in Cancer Risk, Prevention and Treatment

    Phase
    not listed
    Recruiting in
    Los Angeles
    Last updated

  185. Registry for Intra-Operative Radiotherapy During Breast Conserving Surgery in Patients With Early Stage Breast Cancer

    Phase
    not listed
    Recruiting in
    Santa Monica
    Last updated

  186. Autologous huMNC2-CAR44 or huMNC2-CAR22 T Cells for Breast Cancer Targeting Cleaved Form of MUC1 (MUC1*)

    Phase
    1
    Recruiting in
    Duarte
    Last updated

Not sure where to start?

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Frequently asked questions

Which details matter most when looking for a breast cancer study?

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A clinical trial is a research study with people. It tests whether a new medicine, combination, procedure or approach is safe and how well it works compared with what is used today. Taking part is always voluntary, and you can leave a study at any time.

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